Why can't I open PDFs anymore and Adobe Reader won't install.

Why can't I open PDFs anymore and Adobe Reader won't install? This happens only in Safari. I have tried changing my security preferences but it doesn't help.

missyzz,
which version of OS X is installed on your Mac, and which version of Adobe Reader do you have installed? Did you ensure that all of your browsers were not running when you’d installed Adobe Reader?
To use Preview to open PDFs, download the PDFs to your Mac, and then use Preview to open the PDFs locally. Since you can open PDFs in Firefox, it sounds like you don’t need the Preview workaround.

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