Why can't I use the paintbrush tool?

I'm trying to paint on an image and when I mouse over where I want to paint I get the "prohibited" symbol and can't paint. I opened other .jpgs and was able to paint with no problem. Is there a type of file that you can't use the paintbrush tool on? Please help!

I found this to be a way around this issue:
Open the image that you want to draw on, keep that in its own RGB window.
Open a brand new document, CMYK.
Activate your Brush and draw a few lines on your artboard.
Then, copy and paste your RGB image into this new CMYK color space.
Voila. I think the Brush can only be used in a CMYK color space. And sometimes this does not work when you convert your document to a color space inside the RGB document.
Hope this helps. If anyone else has an alternative, let me know.
I've always had this issue with the Brush.

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