Will saving a 750mb photoshop drawing placed on indesign and saved as pdf reduce the image quality??

The pdf seems to be 25mb and I saved it as a high resolution pdf. Will the quality of the psd drawing remain exactly the same??

The resolution of the linked .psd will be depend on if you scale it after placing (the Effective PPI) and your settings in the Export dialog, where you can choose to both downsample and or compress the image, or do neither.
1 GB is a pretty large image. Can you tell us more about it, and what the intended output is? I used to work with images that large on occasion for printing wall-size output, but I'm not sure you would need anything like that kind of size for poster-size and smaller.

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