10.6.4 update - external HD dead

Did the 10.6.4 upgrade (backed up to Time Machine before doing so) - on last generation 15" Macbook Pro.
After the upgrade tried to access external USB Hardrive (that houses Time Machine) - newish little 500gb LaCie - but the drive won't show up at all.
Tells me "The disk you inserted was not readable by this computer" and it needs Initializing when I plug in the SUB cable or start up with it plugged in.
Disk Utiliy can't see it.
Repaired permissions etc. on the Macbook
Still nothing
Any suggestions?
(I've hunted through a bunch of the 10.6.4 issues and done some searches on here - but so many posts - couldn't find anything)
thanks

Zap the Pram after powering down and disconnecting the HD. Boot normally, hook up the HD, and see if that fixes the issue. If not, see what LaCie says.

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