10.6.8 Update hanging up up system?

My 17" 2.9 GHz Intel Core 2 Duo - 4 GB Memory Laptop is sluggish after a reboot.
Programs can't launch from the finder for several minutes.
Programs set to Launch at Login will work, but you can't touch them with the mouse.
Safe Boot will make things work right away, but Safari will lock up!
What should I do?

Repair permissions. I do mine pretty regulary and at first it normally only displays a couple minutes but this time it displayed 12 Minutes and went up from there.
Clear the caches ~/Library/Caches delete the entire folder.
I also noticed a small slowdown when I updated.
Chris

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