2 iPhones and 1 Computer PLUS can I sync one phone in two places?

Wonderful people of the community... I need some guidance.
My spouse and I both have iPhones now. Can both be synced to the same computer without problems or do I need to create a new account on the computer for my wife? Do I need to create a new iTunes account for her?
Also, is there a way that she can sync her iPhone at our home computer for her contacts, music, videos, etc. on our iMac and then sync it at her office for just the calendar items?
Thanks for your help

"Can both be synced to the same computer"
Yes. My wife and I do this. You can sync as many as you like to one computer. Each is a different device and can be set up to sync whatever you like.
"Also, is there a way that she can sync her iPhone at our home computer for her contacts, music, videos, etc. on our iMac and then sync it at her office for just the calendar items?"
Yes. Disable automatic syncing on both computers - to avoid an accidental sync. Then set the work computer to sync calendar and not to sync anything else ( done via the taps in itunes). Do the same at home, only select to sync everything but calendar.

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