2010 Macbook Pro no longer recognizes drive, tried replacing HD+cable

Hello,
About a week ago during user sign-in my 2010 13" Macbook Pro froze. I forced restarted. Upon restart, I got the dreaded screen with the question mark folder. I did the usual, booted from the install CD. Installer couldn't locate drive to install to. Nor could disk utlity to repair anything. I suspected HD failure, so I replaced the drive with one I had on hand. The new HD was still not recognized by the system. I did put the old original drive back in, just to test it, and it actually did boot 1 time, but froze almost immediately. I put the drive in an external SATA enclosure and booted from USB. Booted fine, pulled off all my files, etc. So I then replaced the SATA cable. After replacing it, the computer did recognize the drive, but only if I held Option and told it to boot from the internal HD. Now I'm not getting the question-mark folder (unless I don't do the Option-select drive, in which case, if I do a normal power-button boot, I stlll get the question-mark folder), but instead, after selecting the drive, I'm getting a grey-screen with crossed-out circle (kernal panic?).
Everything else seems to be working fine. I took it to an Apple Store, he ran a diagnostic on it, and all he could tell me was that the HD isn't being recognized. Is my motherboard or SATA port on the motherboard shot or something? If the MoBo shot, why would we go from not seeing the drive at all (hence the question-mark folder and it not being recognized under any situation), to me replacing the SATA cable and getting the supposed kernal panic symbol.
Any thoughts?

At the Apple Store, all I was told was that the computer was not recognizing the HD. No more than that. He told me a HD replacement would be upwards of $200. I took it to the Apple Store before I tried to do anthing myself. He suggested that it could either be the HD itself, or the cable. So, seeing as a HD replacment isn't brain surgery, and that I could do it for significantly less than $200, I did it myself. So I replaced the HD, that did nothing. After replacing the HD the computer would still not recognize its existence, under any circumstance. I tried Option, resetting PRAM, booting into recovery, booting from the install disk, launching disk utility, running the hardware diagnostic from the CD ... under all cases, the HD was not recognized. Seeing as it still wasn't recognized even with the new drive,  I replaced the SATA cable. Again, as stated in my description above, replacing the cable only changed the problem from not recognizing the HD at all, to recognizing it now (when, and only when I hold Option) and booting to the crossed-out circle screen. It doesn't even recognize it every time I hold Option to launch the StartUp Manager. Only a few times out of 10 will it even recognize its there. I also tried, once again, doing all the usual - resetting PRAM, CD install, recover, disk utility, etc... and none of those ever recognize its there. Its only the rare case that it will recognize the new-drive and new-cable configuration in the StartUp manager, I select the drive, and it boots only to the crossed-out circle grey screen.
I have put the original drive in an external SATA enclosure and the computer will boot from it and works fine, except as would be expected, its incredibly slow because its running through a USB port instead of a SATA connection.

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