451 4.4.0 Primary target IP address responded with: "421 4.2.1 Unable to Connec

server 2012 r2 full udpate with current state dc, exchange 2013 sp1 cumulative update 7 patch installed on
new fresh setup, will use exchange with outside mail hosting domain and will send mails via smart host, this already setted up
mapilab pop3 connector will get mails and deliver to exchange mailboxes
int his scenario
we can send mail to any domain from exchange owa like gmail,hotmail etc... no problems so far
however can not send email within exchange mailboxes getting the 451 4.4.0 error as the header states
There is no mail in any of our exchange inbox all stays at quoue with the error above
checked dns, firewall, av everything for 2 days no solution
help please

Hi Mehmet,
Thank you for your question.
From your original post, do you mean the pop account of the user can send emails successfully but the Exchange account of the user failed to send external emails? If there are any misunderstanding, please correct me.
Because email was sent by smart host, when we create send connector, send connector must point smart host instead of MX record.
Configuring smart host could refer to the following link:
http://technet.microsoft.com/en-us/library/cc779371(v=ws.10).aspx
Creating a send connector to route outbound email through a smart host by the following link:
http://technet.microsoft.com/en-us/library/jj673059(v=exchg.150).aspx
We could use tool (for example: ExTRA) to analysis mail flow by the following link:
http://blogs.technet.com/b/exchange/archive/2006/08/07/3394688.aspx
we could refer to the following links to troubleshoot:
https://social.technet.microsoft.com/Forums/en-US/4918c353-c6f7-466a-9d21-66f7bf732761/451-440-primary-target-ip-address-responded-with-421-421-unable-to-connect?forum=exchangesvrsecuremessaginglegacy
https://social.technet.microsoft.com/Forums/en-US/66e3759d-571a-4740-8124-e95c6b7c14bd/451-440-primary-target-ip-address-responded-with-421-421?forum=exchangesvrsecuremessaginglegacy
If there are any questions regarding this issue, please be free to let me know. 
Best Regard,
Jim

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  • 451 4.4.0 primary target IP address responded with 421 4.4.2 unable to connect

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  • Email Stuck - SMTP Relay To Remote Active Directory Site 451 4.4.0 Primary target IP address responded with: ""421 4.4.2 Connection dropped due to SocketError

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    Endrik | blog: itendrik.wordpress.com Please remember to click “Mark as Answer” on the post that helps you, and to click “Unmark as Answer” if a marked post does not actually answer your question. This can be beneficial to other community members reading
    the thread.

    Hi Niko, 
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    Endrik
    Endrik | blog: itendrik.wordpress.com Please remember to click “Mark as Answer” on the post that helps you, and to click “Unmark as Answer” if a marked post does not actually answer your question. This can be beneficial to other community members reading
    the thread.

  • Primary target ip address responded with 421.4.4.2 connection dropped due to socket error

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