Acrobat 8 Pro won't let me save over files

This is just really bugging me - I work in Indesign CS5 and save file as a pdf. I open pdf too check ok and email to client. Then when I amend my Indesign file and resave over that pdf I get this message everytime:
Cannot save to the file "XXX" You may not have permission or the file may be in use.
And consequently, I have to go into the folder and delete it before I can save. It's not in use, it's definitely closed!
Does anyone else have this problem?

Same here Suzie - on my Mac all I'm doing is creating a simple PDF from ID. When I alter it and export as PDF, saving to the desktop to overwrite the previous version it goes through the motions - then up comes this message.
If Bill is assuming correctly that you're on Windows then its a Mac OSX problem too.
Acrobat is dormant here - only ID open.

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