Acrobat Reader X Won't Open/Launch

Hello All,
I have a user running Windows XP Pro (fully patched) and has had Reader X installed for some time - yesterday the user attempted to open a PDF, but Reader would not open.  I've been digging into this issue since then.  The box is clean, no virus/malware infection.  I have uninstalled (and completely removed all Adobe directories) Reader X and reinstalled (rebooting as well) several times with no success - Reader simply wll not open ... this has been tested with all antivirus software completely disabled as well.  I've also attempted to launch Reader X within a new profile on the box, no change.
Any advice on what the issue could be / how to rectify it?
Many Thanks,
Kenneth

Hi Kenneth, I am having this same issue but I am in a domain controlled environment.  What I discovered is that I had to go to the actual exe file in C:\Program Files\Adobe\Reader 10.0\Reader\AcroRd32.exe then right click on the exe, run as local administrator.  Then I got a pop-up talking about this protected mode that I have seen in other places.  I chose to ALWAYS open with protected mode disabled.  Then my reader opened and worked perfectly.  UNTIL I closed it and tried to open it again as my user.  My problem is that I can't even get to the settings as my user to be able to disable protected mode.  It seems the setting change is user to user not system wide.  I hope this helps.  Hopefully though I can get some help on being able to disable protected mode for the whole system.  I currently can't find a registry key...there must be one!!

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