Added RAM and now Applications won't open

I just added RAM (8GB)to my computer and now my InDesign will not open.
I did the OptApple+PR reset.
Do I need to do something after upgrading RAM so things run smooth?

Will the computer start up normally? If not, is the led on the front blinking? If it does start up normally how much RAM does it think it has?
Have you tried going back to the original RAM?

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