Adobe Acrobat Standard/Pro freezing when opening large PDF documents

Ok, I have a tough one. Adobe Acrobat X Standard/Pro keeps freezing when opening large documents that exceed approx. 50 pages. These PDF documents contain large images and graphs for mining purposes, but no links. The issue impacts multiple users on multiple laptops/desktops. We have tried the following:
- Uninstalling/re-installing Adobe Acrobat
- Disabling Enhanced Security in Acrobat Preferences
- Resetting local user profiles
- Changing Reading Preferences to view current visible pages only
- Installing Adobe Acrobat XI
This issue has only occurred after upgrading users to a Windows 7 Enterprise 64bit Operating System.
The only possible solution I have managed to find is changing a registry key that permanently disables the Enhanced Security options in Acrobat. This solution however, only worked on brand new user profiles. Resetting user profiles throughout our entire company is not something we are even going to consider.
If anyone would like more information that I have missed, please feel free to ask.

Another possibility to check is the free space in the TEMP folder. I believe Acrobat uses the TEMP folder for temporary storage. You might even consider increasing the size of the TEMP folder. At least this is something else to check.

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