Adobe CS5, Chrome and Office 2011 Crashing in Lion, plus video issues

Question

Upgraded from Snow Leopard to Lion (in place rather than wiping disk clean).
Adobe InDesign CS5 will start and bring up the main dialog box and crash everytime within a few seconds. Photoshop was also crashing, but it isn't crashing under a new user account. InDesign still is.
I checked the permissions on the library folders, reset the prefs files. It will start up and be useful in safe mode, so I'm looking to isolate the issue.
Microsoft Word (2011) is crashing, but Excel works.
Chrome crashes everytime. Firefox is slow.
System prefs has crashed once.
Text Edit crashes when printing.
Flash video is not playing on anything.
Any thoughts on cause?

Answer 1

I found my solution. Wipe it all out and start fresh!
You have to create a startup drive for Lion to do a clean install. Here's a way:
http://www.trickyways.com/2011/07/how-to-make-mac-os-x-lion-10-7-bootable-usb-fl ash-drive/
If you can't locate your Lion installer, open your App Store and Option-click the purchases tab. This will allow you to redownload the installer.
Back up your stuff (or you'll lose your files).
Startup from your new Lion Install disk (restart and hold the option key.)
Use disk utility to wipe out your hard drive (if you've backed it up, of course)
Reinstall Lion.
Reinstall your applications and have fun rebuilding your life!
All of my issues have gone away and I am once again a happy Apple customer. CS5 works, Office works, Flash video works - everything works!