Adobe will not open

Orignally started with adobe X. I have uninstalled and reinstalled with adobe XI. Even removed all registry entries. Any idea's?

Disabling Protected Mode did not work for me. I did NOT try auto-repairing (Control Panel >Add Remove Programs > Adobe Reader XI > Change > Repair).
What worked for me was:
- go to Task Manager
- find all instances of "Acrobat Reader" (file name is AcroRd32.exe) and end all of these processes
- find "Adobe Acrobat SpeedLauncher" (file name is reader_sl.exe) and end the process (note: skip this step and the issue will not disappear)
- launch Acrobat Reader - it should open this time
- accept EULA if it was not yet accepted
Before I did the steps above:
- Acrobat Reader was not starting when I was double-clicking on a PDF file
- Acrobat Reader was not starting when I was trying to open it directly
- A new instance of AcroRd32.exe process was appearing in the Task Manager every time I tried one of the above actions. This resulted in a couple of AcroRd32.exe processes running in parallel after some time. Killing all of these processes and trying to open Acrobat Reader again did not resolve the issue. The missing step was killing reader_sl.exe process.

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