Advice needed: Cannot boot from new external SATA drive/enclosure.

I replaced my two internal drives with 1Tb Seagate ST31000340AS drives.
I also bought a Mercury Elite Pro external enclosure from Other World Computing (OWCMEFW924AL2K) and populated that with two more of the same drives.
I have RAID disabled and am using Super Duper! to backup/clone my two internal drives to the two external drives. The drives are all working fine, as are all the possible connections (USB2, FW400 and FW800).
After a backup/clone, the Disk Info in Disk Utility shows the external system drive clone to be bootable (which it should be, as my previous external drives were). However, any attempt to boot from the drive via the launch-option key method or by changing the startup disk in the preference panes fails. With the latter I get a brief blinking folder question mark, then it reverts to booting from the internal system drive. With the former, I am not even shown the external drive as a boot volume.
So, what could possible going on here? All the hardware and cables check out, and in all the time I've used Super Duper! it has always created bootable backup drives.
I have tried both FW400 and FW800 connections for the boot, and nada.
I'm really at a loss to explain what might be going on.

After a lengthy live support session last night, and a further phone call to their tech support today, we both realized we had run out of ALL options to fix the problem. (There is nothing you could imagine that we didn't try).
In the end, OWC were kind enough to offer an overnight crosship of a replacement enclosure. I guess their suspicion is that there is a defect on the board in the enclosure. We'll see once I get the replacement...

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    Number of Folders :
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    Can Be Formatted :
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    Bootable :
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    Supports Journaling :
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    Journaled :
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    Disk Number :
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    Partition Number :
    2
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    I repaired all I could before the cloning of the drive, only the deep maintenance of DiskWarrior was skipped. With the disk or the OS itself, I basically did what you can, even the stuff that you are rarely supposed to do. (Onyx is a great tool to do all these and more, freely.)
    I am not sure either that a FireWire drive would have helped, but who knows. (But really, the OS would boot, just the applications would feel that their are on an 'inferior' drive?) In any case, FireWire drives are not that easy to come by, and a risky investment -- e.g. I could not use them with the new MacBooks. Oh, and all my work was done on a firm table, but again, the behavior would be hard to explain as the HDD misbehaving, as the OS had no glitch, just I could not start applications without their crashing immediately.
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