After clearing cash on mac applications won't lunch any more..I tried to delete apps like VLC player with app cleaner and again download and instal new but it's the same..goes for all apps that are not originally part of Yosemite. Please advise me?!

After clearing cash on my mac ( Go to folder: ~/Library/Caches and clear all, than to Library/Cashes and clear all again) applications won't lunch any more..I tried to delete apps like VLC player, firefox.. with app cleaner and again download and install the new one but it's the same..goes for all apps that are not originally part of Yosemite. I have done this cash clean up very often on Maverick without any problems. This time I done it again because I could not open my web site, the server has blocked me and I was trying everything including deleting cash from mac. Please advise me what to do..?!? Thanks in advance.

It sounds like you may have multiple problems, but none of them are likely to be caused by malware.
First, the internet-related issues may be related to adware or a network compromise. I tend to lean more towards the latter, based on your description of the problem. See:
http://www.adwaremedic.com/kb/baddns.php
http://www.adwaremedic.com/kb/hackedrouter.php
If investigation shows that this is not a network-specific issue, then it's probably adware. See my Adware Removal Guide for help finding and removing it. Note that you mention AdBlock as if it should have prevented this, but it's important to understand that ad blockers do not protect you against adware in any way. Neither would any kind of anti-virus software, which often doesn't detect adware.
As for the other issues, it sounds like you've got some serious corruption. I would be inclined to say it sounds like a failing drive, except it sounds like you just got it replaced. How did you get all your files back after the new drive was installed?
(Fair disclosure: I may receive compensation from links to my sites, TheSafeMac.com and AdwareMedic.com, in the form of buttons allowing for donations. Donations are not required to use my site or software.)

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