After installing a required update, many of my normal applications (Word, Chrome, Adobe Reader) will simply crash after opening. Why?

I recently installed a required printer (epson) update on my Macbook Pro (running Mt Lion).  After installing and going through the required restart, I discovered that many of my existing applications will not open; instead they simply crash moment after opening.  Prior to the update installation, everything worked fine.  I have gone through the disk utiities program and repaired the various disk permissions that needed changing and still nothing. My MacBook Pro is 4 years old, runs Mt Lion and has plenty of disc space available.  What do I need to do?

Please read this whole message before doing anything.
This procedure is a diagnostic test. It’s unlikely to solve your problem. Don’t be disappointed when you find that nothing has changed after you complete it.
The purpose of the test is to determine whether the problem is caused by third-party software that loads automatically at startup or login, by a peripheral device, or by corruption of certain system caches. 
Disconnect all wired peripherals except those needed for the test, and remove all aftermarket expansion cards. Boot in safe mode and log in to the account with the problem. Note: If FileVault is enabled on some models, or if a firmware password is set, or if the boot volume is a software RAID, you can’t do this. Ask for further instructions.
Safe mode is much slower to boot and run than normal, and some things won’t work at all, including sound output and  Wi-Fi on certain iMacs. The next normal boot may also be somewhat slow.
The login screen appears even if you usually log in automatically. You must know your login password in order to log in. If you’ve forgotten the password, you will need to reset it before you begin. Test while in safe mode. Same problem? After testing, reboot as usual (i.e., not in safe mode) and verify that you still have the problem. Post the results of the test.

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