After software update, icons bounce, apps don't load

I recently returned to my iMac after a three-week absence and all was working normally. I ran software update but didn't take much notice of what was being upgraded. However, I now have 10.6.2 and everything is up to date. However, after rebooting a find that a large number of applications will not load. The applications bounce for a few moments but nothing happens. iCal, Address run normally but almost everything else, including iLife apps, refuse to load.
I've done the usual test, including repairing permissions and running Disk Warrior to make sure everything is ok. At the back of my mind I think I've heard of this problem before but cannot think where. Anyone have any ideas of what might happen.
Note: I ran the same updates on my MacBook Pro and MacBook Air and everything is running normally. The problem is confined to the iMac.

Hmmm, I must be looking with my eyes closed, I cannot find the button to make my own thread. So I'll just hijack this one for the time being :P
I have a similar to Michael. I updated Safari to 4.0.4 last night and not long after booting up and using Safari, and even FF by itself after a while the pages don't display properly and the screen saver stops, system freezes (about half a dozen times now). Dock icons go all weird. I did repair permissions... nothing. I just reset PRAM, worked ok with some problems, but it has just totally froze again.
Reinstall?

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