All Menu Items Greyed Out CS5

Everytime I use Photoshop CS5, at some point all of the menu items get greyed out and don't come back unless I quit and reopen Photoshop.  There doesn't seem to be anything that triggers it.
All the keyboard shortcut and the mouse and tools work fine, but I can't select any of the menu items in the dropdowns in the menu bar (Photoshop, File, Edit, Image, etc)
This is obviously very annoying...any ideas?

Hi
Just to add that it occurred the first, or second time, I booted PhotoShop CS5 on a new i7 10.6.3 machine. All menus without exception were greyed. I discovered it trying Cmd O which didn't work. After a moment being stunned, then stumped, I just instinctively hit the Cmd Q as a last ditch before reaching for the force quit in the Apple menu and was surprised to find it  responded to that keyboard command and quit. Since then (and so far) it's been fine.
I'm desparately trying to think which other app in the Premium Suite did it on first boot too. I think it was Illustrator though I cannot be certain. By then I'd seen it before and dismissed it as "oh that again". The same applied - Cmd Q and reboot = been fine since.
I had installed CS4 on the same brand new machine (no migration so I  know it was a 'clean' machine) just the month before. The CS5 suite was an upgrade as opposed to a new install. I'd not done anything to customise PhotoShop CS4 during the month, as I knew I'd be getting the upgrade and my work was mostly in the other apps.
The other apps in the Premium Suite haven't done this particular party trick to me... yet.
Whether this tells anyone anything, or helps point the way to the 'cocoa event', I don't know, but I thought I'd add my experience just incase it does help. Is there anywhere where this might be recorded? I'm pretty confident with the Mac and happy to supply info.

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