All programs keep "not responding"

I am a new mac user (roughly 6 months) I had tiger for about 2 months before leopard came out. I am not sure where to even start with this. All the programs I use constantly "not respond" Firefox was so buggy I switched to Safari thinking it was FF but now Safari doesn't respond just as much as FF did. My mail, ical, pocketmac for blackberry, word 2008, are the common programs I use and I am constantly forcing a quit b/c they are freezing on me. What can I do. I am unaware where to even start diagnosing this. ANY advise would be great, but I am tempting to go back to tiger but then I would lose timemachine......
Please note all programs are running updated

What does your last post mean that running Repair Permissions and Disk Utility did not sort it?
If that's the case then create a new account, name it "test" and see how your apps work in that User acct? (That will tell if your problem is systemwide or limited to your User acct.) This account is just for test, do nothing further with it.
Open System Preferences >> Accounts >> "+" make it an admin account.
If the problem is present in the test account also, then it is systemwide. In this case try repairing this with the 10.5.2 Combo Update This is a fuller install, as opposed to an incremental "delta" update so it should overwrite any files that are damaged or missing. It does not matter if you have applied it before.
Remember to Verify Disk before update and repair permissions after update from /Applications/Utilities/Disk Utility.
If the problem does not appear in the test account try starting in "Safe Mode" (It will take a bit more time to startup because it runs a directory check first).
If that works go to System Preferences >> Accounts >> Login Items and remove them. Boot normally and test. If there are still problems, go to ~(yourHome)/Library/Contextual Menu Items and move whatever is there to the desktop. Then do the same with /Library/Contextual Menu Items. Lastly, try moving /Users/Home)/Library/Fonts to your desktop and restarting.
Log out/in or restart, if that sorts it start putting items back one at a time until you find the culprit.
Let us know.
-mj

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