Any change to my Photoshop Preferences refuses to be saved.

I just got a new Macbook Pro, with Mavericks installed, and my Photoshop CS5 is experiencing issues. Changes to Preferences cannot be saved due to the file being locked or a permissions error.
But when I go into the 'Get Info' panel in Finder:
It says I have "custom access", and Read & Write. I am the only user on this laptop so I assume I am an administrator. Also the option for it to be "locked" is unchecked and greyed out with no indication on how to access it.
I had no issues before I began using this new computer, on my previous Macbook Pro the program worked fine in this regard.
So what is happening? How can I get my Photoshop to save my Preferences changes?
I am using Photoshop CS5 Extended Version 12.0 x64
My computer is specifically a Macbook Pro 13 inches, (mid 2012), with OSX 10.9.1 (it says all updates are installed as well)
The processor is a 2.9 GHz Intel Core i7
The memory is 8 GB 1600 MHz DDR3
And the installed Graphics Card is Intel HD Graphics 4000 1024 MB
I'd really appreciate your help on this matter as it relates to another issue I'm dealing with involving the OpenGL and Video Card graphics accelerators preventing me from using the rotate tool. I suspect I can't do anything about that problem unless I'm able to save changes to my Preferences first.

Hey, I've got the same issue - get the same message.
And I've gone to my Preferences folder - and gave myself Read & Write Access to the folder but I still get that same message above when I quite CS5 Photoshop. And when I look in the Preferences folder - there is not Photoshop. Is there something I'm missing?
Appreciate any assistance.
Thank you.

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