Anyone else having sudden Mail Outgoing Exchange Server problems?

I have a Microsoft Exchange account for work that I have been accessing on Mail for about 2 yrs w/o any problems until last weekend. Then, suddenly, I can't send emails from that account if I originate the email, but I can send it w/o difficulty if I'm replying to an email from that account!
Also, when I do open a new email on that acct, it opens as an iCloud mail, and I have to select my Exchange server in the dropdown. When I do this, it doesn't add in my Signature for that acct, although it does when I'm replying to an email.
I've made no changes to my account or server settings, nor has our Administrator. My Lion/Mail versions are UTD. When I check the Outgoing server info, I notice it keeps deleting it, and marking the server as Offline.
I can log in as a webmail (owa) acct, and can also log in on my PC--same PW, etc.
VERY strange--have been searching Discussions/Help/Knowledge Base since then and trying everything I can think of (with 22+ yrs Mac experience)--to no avail.
Any thoughts from the Mail Gurus out there?

Same thing. I'm in Mexico City right now and Mail stopped working two days into the trip. I reset all my email accounts in Mail and it still wouldn't work. I had to switch to Entourage to recieve and send emails (worked perfectly).  I prefer Mail but I've had this problem before with emails getting hung up. What's going on here?

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