Anyone had problems with apps disappearing when no one has actively deleted them?

My apps keep disappearing. I get the grey question mark through an app yet no one has deleted anything, the app has just gone. Not in trash, not in apps...  Any ideas why?

Hard drives fail. They just do after X amount of time. Nothing new about that. Worrying? Yes if you don't have a backup of your files. That is why both Apple and Microsoft include progams/apps for backing up the system in with the operating systems.
How old is your iMac? Since you are running Snow Leopard 10.6.8 it is at least 2.5 years old if not older.
I'm not saying your drive is on its way out but it could be one cause of the problem you are experiencing.
Open Disk Utility and verify the drive and repair it if needed. But if you do need to do a repair you might want to think about having it replaced.

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