App icons not clickable - any ideas?...

Hello folks.
I have a brand new out-of-the-box iMac 27 with OSX pre-installed. I believe (from when it was running) that it was OSX 10.6.1 (would that be right???) but the install disk, relevantly, is 10.6.4.
It was a joy to use for the first two days but then it refused to accept keystroke entry at the password login screen. I did all of the things the user guides suggested and I can now boot up and log on, but none of the app icons respond to the cursor: no name panel pops up above the icon; the icon doesn't 'jump' and it isn't clickable. Consequently, although I have a functional computer with loaded software, I can't activate anything!
What have I tried? In overcoming the login issue I began with the force quitting and 'all cord remove and replace procedure. I reset the PRAM. I re - installed the OS X. The batteries on the wireless keyboard and mouse are fine and they both connect (the cursor responds) but I have used USB keyboard and mouse to eliminate that variable.
Any ideas??? All tips gratefully received.
Cheers,
pplater.

Not psychic just thought I noticed some rookie issues. Anyhow below are the links to the sites I mentioned they are designed for people considering switching from PC's to Macs and those that recently have. Bookmark them and keep them for future reference, you will find LOTS of useful stuff. Also if you haven't already spend some time reading your owners manual, again you will find lots of useful information.
http://www.apple.com/support/switch101/
http://www.apple.com/support/mac101/
http://www.apple.com/findouthow/mac/

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