App v Outlook unable to open .pdf in IE

Greetings everyone!
So I have a user that is unable to open up any link to a Web site PDF from outlook.  She clicks on the link to the pdf, IE opens, and then she gets this error.
We also stream Adobe reader, which is what Outlook calls on in order to open the pdf.  I entered the Adobe reader bubble and went to the above path and launched the eula.exe.  I was able to accept it, but the issue still persists. 
I went into the Outlook bubble to check and see if the same EULA was present and there was none.
We run App v version 4.6
There are a few users that experience this, but maybe 1% of the environment.  No other users can duplicate the issue. 
We have tried clearing the cache.
Adobe Reader and Outlook 2010 are virtualized as well.
Any thoughts? Any help is greatly appreciated!
Thanks in advance!
NewGenPack

You have a PDF file that has been associated with a  virtual Adobe Reader. Is Outlook virtualized? If so, which version? You have three applications at play here. We need more information. 
Steve Thomas, Senior Consultant, Microsoft
App-V/MED-V/SCVMM/Server App-V/MDOP/AppCompat
http://blogs.technet.com/gladiatormsft/
The App-V Team blog: http://blogs.technet.com/appv/
The MED-V Team Blog: http://blogs.technet.com/medv
The SCVMM Team blog: http://blogs.technet.com/scvmm/
“This posting is provided "AS IS" with no warranties, and confers no rights. User assumes all risks.”

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