Apple Mouse won't open files

My trustee old iMac has never given me any problems until recently. When I try to open a file by clicking on it with my mouse, it highlights the file but doesn't open it. I can open flies by using Open File. I have tried another Apple mouse but no luck. I run several legacy OS 9 programs on this iMac that don't run on my other iMacs so would like to find solution. Appreciate any suggestions.

I take it you've restarted the computer and tested to see if the problem persists? If not, that's Step One. A restart can often be a big help.
Step Two would be to connect the mouse directly to one of the USB ports if it's not already and test. Sometimes keyboard problem can keep the mouse from working properly if it's running throuah port on the keyboard. If you have the mouse attached to a non-powered USB hub, the hub alone could be the problem.
Step three is doing some routine maintenance. The easiest thing to do is to repair permissions using Disk Utility, in Applications -> Utilities.
Try those and report back.

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