Application is not working with mouse

Dear All,
We have a strange issue in the our application (Oracle form) in the one of our client machine.
Some times the forms are not able to work with the mouse but is able to work with the keyboard. After one or two machine restart its again working. When the issue occur we can able to work in other applications using mouse.
Our Applications server is in Other country and client are accessing from India.
This occurs for some user and not for all.
Application server Version          10.1.2.0.2.
Oracle Database 11g Enterprise Edition Release 11.2.0.1.0 - 64bit
Java Plug-in version 1.6.0_31 .
Please any info will help us lot.

Thank you for the quick replies Michael Ferrante and HamidHelal.
But since its occurring for some users (perticulary indian users) and some times. And also its occurring in production environment not in development environment.
Even the java control panel is not working with mouse.
For other country customers everything working fine.
So its difficult for me to apply the patch with these uncertainties.
Checking with fresh java installation and let you know the status.
Thanks.

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