Applications and files are all disappearing

After initially having trouble with opening a file in Adobe Lightroom, I have now discovered that everything on my computer is slowing disappearing or erasing itself. For example, I went to go look at my pictures and found that all the folders existed, but there was nothing in them. I also have nothing in my documents. Most of my applications in my dock had a question mark over it, except for those that were open, but when I closed it and tried to reopen, the question mark appeared so now basically I have a dock full of question marks. I then decided to try and open the applications through Finder, only to find them all zero kilobytes in size. While this is the case, when I click on Macintosh HD in Finder and look at the info, it says 500gb have been used despite the fact everything seems to be zero kilobytes. I am at a loss at what to do and would appreciate any help.

WOW!!!
http://support.apple.com/kb/HT2963 - scroll to the *"Application installers, Applications folder"* section.
Disconnect all peripherals from your computer. Boot from your install disc & run _*Repair Disk*_ from the utility menu. To use the Install Mac OS X disc, insert the disc, and restart your computer while holding down the C key as it starts up.
Select your language.
Once on the desktop, select Utility in the menu bar.
Select *Disk Utility.*
Select the disk or volume in the list of disks and volumes, and then click *First Aid.*
Click _*Repair Disk.*_
Restart your computer when done.
Repair permissions after you reach the desktop-http://docs.info.apple.com/article.html?artnum=25751 and restart your computer.
HTH

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