Applications don't respond...too often

Hi Leopards,
Since a couple of weeks I am confronted with a problem that makes my MacPro looking like a Windows machine.
Every now and then, but certainly too often, an application hangs. Today it was the installation of a Microsoft update, but it happens with Adobe Photoshop as well, and even with iTunes when syncing with my iPhone. (Well, actually, iTunes does not hang forever, but it takes several hours to sync, and I think that's a tiny bit too long).
Is this a problem that can only be solved by 'resetting' the whole computer, and what is the easiest way to do that?
Thanks,
Best,
Carlo

Hi Andrew and other Leopards,
Thanks for this solution. I have repaired disk permissions, but to no avail.
At this very moment an Installation program is stalling, and before that Adobe Lightroom was.
Moreover, when I tried to restart the computer after the repair, it stalled, and stalled, and stalled.
Any idea?
Thank you
Carlo

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