Applications not starting or loading

Seems odd my safari, mail adobe reader apps do not open at all. The mail icon will jump up but will not load anything. Any ideas. Seems strange mostly apple apps. Is there an app or something that opens these and is not working.

It does the same thing even in a brand new user account?
Try rebuilding the Launch Services database. You can do that by opening Terminal and copying and pasting these three lines all at the same time, and then pressing return:
/System/Library/Frameworks/ApplicationServices.framework/\
Frameworks/LaunchServices.framework/Support/lsregister \
-kill -r -domain local -domain system -domain user
You could also give your system a thorough hosing down. Try downloading OnyX and running all of the maintenance and cleaning tasks.

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