Applying a patch to my 6.40 install breaks it!

Question

I have a freshly downloaded 6.40 compilation 5 installation.  If I install it after downloading it, it works great.  However, I want to get it up to patch 22 level.  I run sapadmin.exe and apply patch 22 to it, and all goes well with that.
However, from then on, if I launch sapsetup.exe from this patched install, there are nearly hundreds of missing files from the installation, including major dlls, ocxs, etc. 
Some files install fine, others dont.  Here's a snippet from the sapsetup.log of some failures:
20:22:43  SapFeiSv  3   Cabinet Extraction: C:\sapgui640p22\DVD_NW_2004s_SR1_Presentation\PRES1\GUI\WINDOWS\WIN32\CAB\{F270A214-3AD3-4235-9C74-F4D323B54976}.cab to be extracted to C:\WINDOWS\TEMP\sap343\{F270A214-3AD3-4235-9C74-F4D323B54976}\
20:22:43  SapFeiSv  1   Folder created: C:\WINDOWS\TEMP\sap343\{F270A214-3AD3-4235-9C74-F4D323B54976}
20:22:43  SapFeiSv  1   Folder created: C:\WINDOWS\TEMP\sap343\{F270A214-3AD3-4235-9C74-F4D323B54976}\system
20:22:43  SapFeiKr  2   SAP Frontend Installation Kernel initialized
                        (ANSI Release build)
20:22:43  SapFeiSv  1   String not displayed on Progress Dialog
20:22:43  SapFeiSh  1   Trying to load 'C:\sapgui640p22\DVD_NW_2004s_SR1_Presentation\PRES1\GUI\WINDOWS\WIN32\setup\vbscript.dll'...
20:22:43  SapFeiSh  1   "C:\sapgui640p22\DVD_NW_2004s_SR1_Presentation\PRES1\GUI\WINDOWS\WIN32\setup\vbscript.dll" successfully loaded.
20:22:43  SapFeiSv  1   Starting script action...
20:22:43  SapFeiSv  1   Script-action: Checking force condition.
20:22:43  SapFeiKr  2E  Source file 'C:\WINDOWS\TEMP\sap343\{F270A214-3AD3-4235-9C74-F4D323B54976}\system\msvcp60.dll' is missing. Aborting file installation: The system cannot find the file specified.   Error code 0x2 (2)
20:22:43  SapFeiKr  2E  Source file 'C:\WINDOWS\TEMP\sap343\{F270A214-3AD3-4235-9C74-F4D323B54976}\system\msvbvm50.dll' is missing. Aborting file installation: The system cannot find the file specified.   Error code 0x2 (2)
20:22:43  SapFeiKr  2E  Source file 'C:\WINDOWS\TEMP\sap343\{F270A214-3AD3-4235-9C74-F4D323B54976}\system\msvbvm60.dll' is missing. Aborting file installation: The system cannot find the file specified.   Error code 0x2 (2)
20:22:43  SapFeiKr  2E  Source file 'C:\WINDOWS\TEMP\sap343\{F270A214-3AD3-4235-9C74-F4D323B54976}\system\grid32.ocx' is missing. Aborting file installation: The system cannot find the file specified.   Error code 0x2 (2)
20:22:43  SapFeiKr  2E  Source file 'C:\WINDOWS\TEMP\sap343\{F270A214-3AD3-4235-9C74-F4D323B54976}\system\tlbinf32.dll' is missing. Aborting file installation: The system cannot find the file specified.   Error code 0x2 (2)

Answer 1

Hi Russ,
Few things I would like to mention here are :
1. You need to uninstall the GUI 620 which is previously installed and then install the 640 GUI setup. ( Better to take restart before and after installing the new GUI.
2.  As you have successfully installed 640 on one particular PC, you must have followed the above step.
3. Now before applying patch please close all GUI windows ( Again a restart ensures is benificial here ) and now simply run the patch file  setup640_22-10001615.exe  which you have downloaded from service marketplace.
I am sure this will not have any problem.
Please confirm if solved. Otherwise update us on this issue.
Cheers.
Shamish