Are you sure you want to open the application

I get asked "+Are you sure you want to open the application+" when I open htm files e-mailed to me.
Does anyone know to stop this?
It never used to happen with older versions of Safari and Mail.

baltwo,
thanks again for your response.
I have changed that setting a few times with various other changes in different combinations. I rebooted but have not tried repairing permissions yet, will do so in next few days and will let you know result.
Thanks again for your assistance.

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