Associated helper application does not exist

Please bear with me as I'm computer illiterate....
I'm a new Mac user and I don't even know if my problem is Mac related, Adobe Reader (the application) related or Firefox related....
It appears I've been opening PDF files with Preview ever since I got my Mac (I didn't realize this until today, but always wondered about why it would not open in my browser) and lately - for some reason - I'm unable to view PDF files and get the message mentioned in the subject line.
I honestly don't know what to do - I've been struggling with it all day, removing Adobe Reader, re-installing it, etc.
One thing I did find strange was that my list of Download Actions in Firefox was next to empty. Any ideas as to where I should start looking for the cause of this? Any help would be much appreciated. Thanks.

BTW I don't care whether I view it in Preview or Adobe Reader - I just really really need to be able to read my mail from work! TIA

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