Audio playback frequencies are distorted...

All of a sudden, audio playback through my speakers/headphone jack is muddy and distorted.  Sometimes, the vocal track disappears completely.  This is not just in iTunes (where I've unsuccessfully tried to adjust the equalizer), it's also on Youtube videos.  Sonos, which does NOT go thru system audio, sounds fine.  I'm including etrecheck diagnostics.  Thanks for any ideas.  Oh, and the only thing that's changed, systemwise, is the latest Yosemite upgrade.  The problem started after that, but not immediately after.
Problem description:
Audio playback is distorted
EtreCheck version: 2.1.8 (121)
Report generated April 16, 2015 at 11:20:10 PM CDT
Download EtreCheck from http://etresoft.com/etrecheck
Click the [Click for support] links for help with non-Apple products.
Click the [Click for details] links for more information about that line.
Hardware Information: ℹ️
    MacBook Pro (Retina, 13-inch, Late 2013) (Technical Specifications)
    MacBook Pro - model: MacBookPro11,1
    1 2.4 GHz Intel Core i5 CPU: 2-core
    16 GB RAM Not upgradeable
        BANK 0/DIMM0
            8 GB DDR3 1600 MHz ok
        BANK 1/DIMM0
            8 GB DDR3 1600 MHz ok
    Bluetooth: Good - Handoff/Airdrop2 supported
    Wireless:  en0: 802.11 a/b/g/n/ac
    Battery Health: Normal - Cycle count 298
Video Information: ℹ️
    Intel Iris
        Color LCD spdisplays_2560x1600Retina
System Software: ℹ️
    OS X 10.10.3 (14D131) - Time since boot: 1:26:40
Disk Information: ℹ️
    APPLE SSD SD0256F disk0 : (251 GB)
        EFI (disk0s1) <not mounted> : 210 MB
        Macintosh HD (disk0s2) / : 150.14 GB (103.49 GB free)
        Recovery HD (disk0s3) <not mounted>  [Recovery]: 650 MB
        BOOTCAMP (disk0s4) /Volumes/BOOTCAMP : 100.00 GB (26.24 GB free)
USB Information: ℹ️
    Apple Internal Memory Card Reader
    Apple Inc. Apple Internal Keyboard / Trackpad
    Apple Inc. BRCM20702 Hub
        Apple Inc. Bluetooth USB Host Controller
    Maxtor OneTouch 160.04 GB
        OneTouch4 Mini (disk1s1) /Volumes/OneTouch4 Mini : 160.04 GB (116.48 GB free)
    Seagate USB Mass Storage 100.03 GB
        Seagate 100 (disk2s1) /Volumes/Seagate 100 : 100.03 GB (91.52 GB free)
Thunderbolt Information: ℹ️
    Apple Inc. thunderbolt_bus
Gatekeeper: ℹ️
    Mac App Store and identified developers
Kernel Extensions: ℹ️
        /System/Library/Extensions
    [not loaded]    com.bose.bluetooth (1.0.0) [Click for support]
    [not loaded]    com.marvell.kext.USBGenericPrinterClass (1.0.0) [Click for support]
Launch Agents: ℹ️
    [loaded]    com.oracle.java.Java-Updater.plist [Click for support]
    [loaded]    org.gpgtools.gpgmail.enable-bundles.plist [Click for support]
    [loaded]    org.gpgtools.gpgmail.patch-uuid-user.plist [Click for support]
    [loaded]    org.gpgtools.Libmacgpg.xpc.plist [Click for support]
    [loaded]    org.gpgtools.macgpg2.fix.plist [Click for support]
    [running]    org.gpgtools.macgpg2.shutdown-gpg-agent.plist [Click for support]
    [loaded]    org.gpgtools.macgpg2.updater.plist [Click for support]
Launch Daemons: ℹ️
    [loaded]    com.adobe.fpsaud.plist [Click for support]
    [running]    com.fitbit.galileod.plist [Click for support]
    [loaded]    com.oracle.java.Helper-Tool.plist [Click for support]
    [loaded]    com.oracle.java.JavaUpdateHelper.plist [Click for support]
    [loaded]    com.rogueamoeba.instanton-agent.plist [Click for support]
    [loaded]    com.sonos.smbbump.plist [Click for support]
    [loaded]    org.gpgtools.gpgmail.patch-uuid.plist [Click for support]
User Launch Agents: ℹ️
    [loaded]    com.adobe.ARM.[...].plist [Click for support]
    [running]    com.hp.printerAgent.plist [Click for support]
User Login Items: ℹ️
    iTunesHelper    Application  (/Applications/iTunes.app/Contents/MacOS/iTunesHelper.app)
    Dropbox    Application  (/Applications/Dropbox.app)
    Safari    Application  (/Applications/Safari.app)
    Mail    Application  (/Applications/Mail.app)
    AdobeResourceSynchronizer    Application Hidden (/Applications/Adobe Reader.app/Contents/Support/AdobeResourceSynchronizer.app)
    Fitbit Connect Menubar Helper    Application  (/Applications/Fitbit Connect.app/Contents/MacOS/Fitbit Connect Menubar Helper.app)
    Airfoil Speakers    Application Hidden (/Applications/Airfoil Speakers.app)
    Printer Pro Desktop    Application  (/Applications/Printer Pro Desktop.app)
Internet Plug-ins: ℹ️
    FlashPlayer-10.6: Version: 17.0.0.169 - SDK 10.6 [Click for support]
    QuickTime Plugin: Version: 7.7.3
    AdobePDFViewerNPAPI: Version: 11.0.10 - SDK 10.6 [Click for support]
    AdobePDFViewer: Version: 11.0.10 - SDK 10.6 [Click for support]
    Flash Player: Version: 17.0.0.169 - SDK 10.6 [Click for support]
    Default Browser: Version: 600 - SDK 10.10
    Silverlight: Version: 5.1.30514.0 - SDK 10.6 [Click for support]
    JavaAppletPlugin: Version: Java 8 Update 31 Check version
User internet Plug-ins: ℹ️
    Stamps.com: Version: 1.1.13 [Click for support]
Safari Extensions: ℹ️
    1-ClickWeather
    Adblock Plus
    SafariRestore
3rd Party Preference Panes: ℹ️
    Flash Player  [Click for support]
    GPGPreferences  [Click for support]
    Java  [Click for support]
Time Machine: ℹ️
    Skip System Files: NO
    Mobile backups: ON
    Auto backup: YES
    Volumes being backed up:
        Macintosh HD: Disk size: 150.14 GB Disk used: 46.65 GB
    Destinations:
        Data [Network]
        Total size: 497.62 GB
        Total number of backups: 55
        Oldest backup: 2014-03-29 22:27:52 +0000
        Last backup: 2015-04-17 03:29:42 +0000
        Size of backup disk: Excellent
            Backup size 497.62 GB > (Disk size 150.14 GB X 3)
Top Processes by CPU: ℹ️
         4%    WindowServer
         1%    fontd
         0%    Fitbit Connect Menubar Helper
         0%    Dropbox
         0%    AppleSpell
Top Processes by Memory: ℹ️
    361 MB    Safari
    100 MB    com.apple.WebKit.WebContent
    86 MB    mds_stores
    86 MB    Mail
    86 MB    WindowServer
Virtual Memory Information: ℹ️
    10.03 GB    Free RAM
    5.01 GB    Active RAM
    571 MB    Inactive RAM
    1.57 GB    Wired RAM
    1.63 GB    Page-ins
    0 B    Page-outs
Diagnostics Information: ℹ️
    Apr 16, 2015, 09:53:12 PM    Self test - passed
    Apr 16, 2015, 11:11:30 AM    /Library/Logs/DiagnosticReports/CalendarAgent_2015-04-16-111130_[redacted].cras h
    Apr 15, 2015, 12:23:01 PM    /Library/Logs/DiagnosticReports/com.apple.WebKit.WebContent_2015-04-15-122301_[ redacted].cpu_resource.diag [Click for details]
    Apr 14, 2015, 06:55:26 PM    /Users/[redacted]/Library/Logs/DiagnosticReports/Mail_2015-04-14-185526_[redact ed].crash
    Apr 14, 2015, 02:47:54 AM    /Library/Logs/DiagnosticReports/CalendarAgent_2015-04-14-024754_[redacted].cras h

Will try.  There are no cables/exterior connections involved here.
Oddly enough, this worked.  I was unable to hear anything in Safe Mode, so just exited and rebooted (yes, I'd already tried rebooting, with no effect).  Gave iTunes a shot, and am now back to normal.
Whatever works!
Thank you.
bkb

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