Audio problems and more after updating to 10.4.3

After taking an OS X update to 10.4.3 from 10.4.2, I've got static instead of audio. This happens no matter what program I'm using: Bias Peak 4.14, iTunes 6.0.1, Apple DVD Player 4.6, QuickTime 7.0.3. I'm even getting static on system sounds (empty trash, delete file, etc). If I open 'Sound' in System Prefs, I'm treated to continuous static...
My sound card settings have not changed - it's an M-Audio Audiophile 2496 running driver version 2.0.4. I've tried contacting M-Audio tech support but they're closed on weekends.
Everything was ok before I took the update. Now i've got the static and other weird problems as well:
If I try to play a .vob file from a commercially pressed DVD using VLC Media Player, I get the following error message "read failed - permission denied". Anything from a recordable DVD is fine (except for the audio).
If I try to backup any file from a commercially pressed DVD, the file doesn't copy and an error message appears: "The operation cannot be completed because you do not have sufficient privileges for some of the items". I double-checked with a DVD that I had previously backed up successfully using the same method and now it doesn't work.
Any thoughts or suggestions will be most welcome.

This was resolved by repair disc

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