Avoid further changes in requisition once converted to PO

Hello..
I have a question....
It is possible to avoid further changes in requisition once converted into a PO??
I know that I can controll that via authorization by removing the ME52/ME52N transaction.. but I want to know if there is a way to control that via customizing?

This is Not Possible thru Standard SAP.
You Can Control PR Line Items for Further Processings but You Cannot Control Users to add New Line items in PR.
Try the Following Enhancement on PR
MEREQ001  Customers' Own Data in Purchase Requisition
You can use this enhancement to:
o   Maintain/supply your own customer fields in purchase requisitions
o   Update your own customer-specific tables
o   Change standard fields to a limited extent

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