Backing up and cleaning up my Macbook Pro

Hi,
I've been using a Macbook Pro 2.2 GHz Intel i7 for just over a year now and my hard drive is full to the brim. I have recently noticed how much slower the whole system is and so have bought a 3TB Seagate desk top external hard drive and want to back up my whole system and clean up my Macbook Pro. This is the first time I've done this, so I would really appreciate some step by step advice.
I would like to know how best to copy all my files and documents to the drive so I can delete them in vast quantities from my Macbook, knowing that it is all safely backed up and accessible from the external drive. I've also been advised to install extra RAM, which would enhance the speed when running two programmes (Final Cut Pro and After Effects, most regularly). Basically, I would like to clean things up so my system runs as smoothly as it did when first out of the box.
Could you please offer some advice as to how I should go about doing this? Is there a process that I should be following in order to clean up my computer so everything is safely backed up? What other areas of my hard drive that I don't even know about should I be going into to free up space (caches, etc) .The Seagate is literally just out of the box.
Cheers,
Nick

I would suggest using Disk Utility to make two partitions on the Seagate, one the same size as your internal HD, the other for the remainder.
Then use Carbon Copy Cloner or similar to clone your internal disk, so that your Seagate is a bootable backup in case of problems.
Don't worry about caches, temporary files etc - let the OS take care of them.
You could then copy the contents of one of your big directories to the other partition on the Seagate, then delete from the internal disk and empty trash.
But longer term, use the Seagate as backup and internal as working, so I would suggest putting say a 1TB hard disk in place of your Superdrive and moving your bigger directories to that. Now all work is internal, with OS stuff on the original and your stuff on the not-yet-purchased disk, and when you backup (maybe every month for OS stuff, every week or even every day for work stuff) the OS stuff goes to one Seagate partition, the work stuff to the other. You have a bootable clone if your startup disk fails, and a backup of your work. For backing up to the work partition you could consider using Time Machine, so that you have several generations of security from accidental deletes, woopsies etc.

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