Basic clicking issue in specific user accounts, very strange.

Very recently my 2011 15" Macbook Pro is unresponsive to many normal click functions: so far this has included: playing a song in itunes (i mean literally clicking on a song as I've done 1000's of times and getting no playback), trying to blow up a photo in iphoto from a group of photos, or even opening an application from the Application folder. These are all basic one click or double click functions) However, opening apps from the Dock is fine, I can even Drag an application down from finder to the dock and it will open just fine. Internet Apps like Firefox, which I am using to type this work completely normally. To add another level of mystery, I tried creating a new user and everything seems to work fine in that account...what does it all mean?...life?

here is the full result in safe boot
Hardware Information:
          MacBook Pro (15-inch, Early 2011)
          MacBook Pro - model: MacBookPro8,2
          1 2 GHz Intel Core i7 CPU: 4 cores
          4 GB RAM
Video Information:
          AMD Radeon HD 6490M - VRAM: 256 MB
          Intel HD Graphics 3000 - VRAM: 384 MB
Startup Items:
          M-Audio Firmware Loader - Path: /Library/StartupItems/M-Audio Firmware Loader
System Software:
          Mac OS X 10.6.8 (10K549) - Uptime: 0 days 0:4:11
Disk Information:
          TOSHIBA MK5065GSXF disk0 : (465.76 GB)
                    (null) (disk0s1) <not mounted>: 200 MB
                    Macintosh HD (disk0s2) /: 465.44 GB (206.24 GB free)
          MATSHITADVD-R UJ-898
USB Information:
          Loud Technologies Inc. Onyx Blackjack
          Apple Computer, Inc. IR Receiver
          Apple Inc. FaceTime HD Camera (Built-in)
          Mitsumi Electric Apple Optical USB Mouse
          Apple Inc. Apple Internal Keyboard / Trackpad
          Apple Inc. BRCM2070 Hub
                    Apple Inc. Bluetooth USB Host Controller
FireWire Information:
Thunderbolt Information:
          Apple, Inc. MacBook Pro
Kernel Extensions:
          at.obdev.nke.LittleSnitch          (2.3.04)
Problem System Launch Daemons:
          [not loaded] org.samba.winbindd.plist
Problem System Launch Agents:
          [failed] com.apple.Kerberos.renew.plist
Launch Daemons:
          [not loaded] at.obdev.littlesnitchd.plist
          [not loaded] com.adobe.fpsaud.plist
          [not loaded] com.adobe.versioncueCS3.plist
          [not loaded] tc.tctechnologies.Saffire.plist
Launch Agents:
          [not loaded] at.obdev.LittleSnitchNetworkMonitor.plist
          [not loaded] at.obdev.LittleSnitchUIAgent.plist
          [not loaded] com.motu.MOTULauncher.plist
User Launch Agents:
          [not loaded] com.google.keystone.agent.plist
User Login Items:
          Google Drive
          Dropbox
3rd Party Preference Panes:
          Adobe Version Cue CS3
          Flash Player
          PreferencesPane
Internet Plug-ins:
          AdobePDFViewer.plugin
          Flash Player.plugin
          FlashPlayer-10.6.plugin
          iPhotoPhotocast.plugin
          JavaAppletPlugin.plugin
          QuickTime Plugin.plugin
          Silverlight.plugin
User Internet Plug-ins:
Bad Fonts:
          None
Top Processes by CPU:
              16%          lsregister
               8%          EtreCheck
               6%          WindowServer
               5%          syslogd
               5%          coreservicesd
               1%          fontd
               0%          Finder
               0%          distnoted
               0%          SystemUIServer
               0%          notifyd
Top Processes by Memory:
          45 MB    quicklookd
          41 MB    EtreCheck
          37 MB    Dock
          37 MB    Finder
          33 MB    SystemUIServer
          25 MB    System Events
          25 MB    WindowServer
          20 MB    UserEventAgent
          20 MB    loginwindow
          16 MB    kextd
Virtual Memory Statistics
          1.40 GB Free RAM
          334 MB Active RAM
          210 MB Inactive RAM
          2.06 GB Wired RAM
          91 MB    Page-ins
          0 B      Page-outs

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