Best External Hard Drive for Carbon Copy Cloner?

I'm about to do a clean install of Leopard on my *Mac Pro* but I want to back up/clone my current system (10.4.11) to an *external hard drive* first. Based on the recommendations of similar users (Logic Studio) -- a clean install is preferable to an upgrade from Tiger to Leopard. I plan to use *Carbon Copy Cloner* to clone my current system but am unclear as to whether I can use an *external USB drive* versus an external Firewire drive.
Some people claim that firewire is much faster and more reliable for transferring/backing up data, and more importantly, that it's the only type of external hard drive one can boot from -- but I'm not sure that's true for these Intel-based Macs.
Also, I currently use an *Apogee Ensemble* audio interface which does not like sharing the firewire bus with other peripherals. I've also heard references to a external hard drive chipset called 911+ as being important but I think this may only be in regard to firewire.
Bottom line, _can I use an external USB drive with Carbon Copy Cloner on an Intel-based Mac?_
I'm looking for something around 500 Gigs that can sit on my desk with a minimal footprint. I'd like to partition it into three volumes -- the first for the Tiger clone; the second for weekly Leopard back-up; and the third for sound library storage. I'll likely need to access the third volume in realtime from *Logic Pro 8* (audio application) so the HD should be pretty fast. Recommendations?

So Kappy & Hatter...
Allow me to spell this out in practical terms. I'm installing Logic Pro, an audio production application. The consensus is that best results are achieved by installing the application on the internal system drive in bay #1 on the Mac Pro.
Most professional users of Logic Pro recommend a second internal drive in bay #2 solely for audio recording even though the app runs on the drive in bay #1. The drive in bay #2 is often a Raptor because of the 10,000 rpm spin rate, beneficial for the recording process.
For sound libraries with large audio samples/loops, often streamed to the app -- a third drive is recommended to store the sound library. It can be internal or external. Many people use external drives for this function on a firewire 800 bus. The emphasis for this drive would be to read quickly and stream the samples quickly. I would assume that a 32MB buffer cache versus 16MB would be beneficial. I was looking for hi-speed if I went the external route -- hence my foray into the realm of eSATA buses, but perhaps I should just get an internal drive for this as I do have drive bays available in the Mac Pro.
Can you recommend drive spex for this task or a particular hard drive for this task of storing and streaming the sound library?

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