Best practices for E-Business R12 WAN Deployment

Hi
Can anyone point me in the direction of a best practices for deployment of Oracle E-Biz R12 (12.1.3) over a WAN.
We will be using F5 routing for the web servers (multi tier) and a port expeditor routine.
What I am hoping to plan for is security and speed.
Anyone got any experience in this type fo deployment?

Please see if below metalink note guides you:-
Symmetrical Network Acceleration with Oracle E-Business Suite Release 12 [ID 967992.1]
Thanks,
JD

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