Best way to prepare file to be saved as a .pdf?

I created some artwork that I made in a Photoshop file at 200ppi that I now want to save as a .PDF that will be sent to a printer for printing. There are no specific instructions for how to prepare the file and no one is available to answer questions. Are there any general guidelines or settings for preparing and saving a .PDF to make sure it prints good?
Thanks.

I think the following settings should work when saving »As a Copy«, to make sure the layered file will not be damaged:
But whether ISOnewspaper26v4 is right for you I don’t know, it’s the newsprint standard in central Europe – no idea about the rest of the world.
And the JPG-compression can be bad on some images, so view the pdf to make sure it is not noticable, in which case you could try saving with ZIP or None compression.
What color is the type?
If it is supposed to be black or gray it might be better to separate the layered (and, depending on the structure, partially flattened or converted to Smart Ojects) file itself and setting it to pure black (0/0/0/100) to avoid registration issues.
Graphics placed as Smart Objects will output as pixels, so unless you re-build them with the Paths pasted in from Illustrator and used as Vector Masks they will not be vector content in the pdf.

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