Bluetooth mouse buttons do not respond but the mouse icon on the screen follows mouse movements.

Running 10.6.8 and replace my wireless mouse with a Microsoft 5000 Bluetooth.  It works fine and then all of the suddon the left, right and wheel will not work.  I replace with my usb apple mouse and it does the same.  I also tried my old apple wireless mouse and it does the same thing.  Can anyone shine some light on this issue.  In order to fix I must reboot the computer.

I have test with my usb mouse and the same thing is happening as well.  It usually happens when I click on an input field in chrome or safari.

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