Booting off external hard drive

I am trying to boot off an external Seagate 160GB USB hard drive. I used SuperDuper to create a full system backup to my drive. When I reboot, I should hold option, right? When I hold option, the grey screen comes up when booting after the chime and then the system reboots again with the chime. It doesn't give me the bootable drive option. Can someone help? Thanks.

hello i have a similar problem with my mac mini i aquired a 160GB western digital drive and cloned my current 40GB seagate drive into it using a software called carbon copy cloner but after replacing the drive the flashing ? appears iv tried almost everything possible i have zapped the pram,reset the nvram and nothing seems to work but i see the drive when i connect to my mac via usb as an external harddrive i guess my question is how do i make my new hard drive bootable since its going to replace my old one in the mac please help.
thanks
aden

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