Bundling Cisco ISE ports

Question

Hello,
Cisco ISE user guide suggests that all 4 ports can be assigned IP addresses and that's that. No suggestions such as if the all ports should be on different VLANs or if the ports can be bundled, hence saving IP address space. I have read the book by ISE expert Aaron Woland and no suggestions either.
On a Standalone ISE, as soon as I configured Gi1 with a different IP subnet from Gi0, I lost GUI access. So my questions are as follows:
1. Can all 4 ports be bundled
2. If no bundling and all 4 ports are assigned IP addresses, can they be on different IP subnets, whether Standalone or Distributed personas. For example a PSN with 4 ports. Gi0 - 10.0.10.x, Gi1 - 172.16.5.x, Gi2 - 172.16.8.x, Gi - 10.2.5.x
Thanks 

Answer 1

The ISE log detailed steps are as follows:
Steps
11001  Received RADIUS Access-Request
11017  RADIUS created a new session
Evaluating Service Selection Policy
15048  Queried PIP
15048  Queried PIP
15004  Matched rule
11507  Extracted EAP-Response/Identity
12300  Prepared EAP-Request proposing PEAP with challenge
12625  Valid EAP-Key-Name attribute received
11006  Returned RADIUS Access-Challenge
11001  Received RADIUS Access-Request
11018  RADIUS is re-using an existing session
12501  Extracted EAP-Response/NAK requesting to use EAP-TLS instead
12500  Prepared EAP-Request proposing EAP-TLS with challenge
12625  Valid EAP-Key-Name attribute received
11006  Returned RADIUS Access-Challenge
11001  Received RADIUS Access-Request
11018  RADIUS is re-using an existing session
12502  Extracted EAP-Response containing EAP-TLS challenge-response and accepting EAP-TLS as negotiated
12800  Extracted first TLS record; TLS handshake started
12805  Extracted TLS ClientHello message
12806  Prepared TLS ServerHello message
12807  Prepared TLS Certificate message
12809  Prepared TLS CertificateRequest message
12505  Prepared EAP-Request with another EAP-TLS challenge
11006  Returned RADIUS Access-Challenge
11001  Received RADIUS Access-Request
11018  RADIUS is re-using an existing session
12504  Extracted EAP-Response containing EAP-TLS challenge-response
12505  Prepared EAP-Request with another EAP-TLS challenge
11006  Returned RADIUS Access-Challenge
11001  Received RADIUS Access-Request
11018  RADIUS is re-using an existing session
12504  Extracted EAP-Response containing EAP-TLS challenge-response
12505  Prepared EAP-Request with another EAP-TLS challenge
11006  Returned RADIUS Access-Challenge
5411  No response received during 120 seconds on last EAP message sent to the client