C:/windows/system32/winspool.drv is not designed to run on window or contains an error

This virus attacks this driver which stops me running mozilla firefox and open office but not microsoft products - suspicious. I have googled this bug and others have it and cannot easily remove it. I have downloaded drivers for my Dell Insprion but there is no winspool.drv.

Taken at face value, you're having trouble with one of the Windows OS dlls associated with Cryptographic Services.
I'd first try the fixit from the following Microsoft document. (One of the things it does is reregister your copy of the dssenh.dll file.)
You cannot install some updates or programs
... but if you still get the issue, I'd try an sfc /scannow as per the instructions in the following document:
How to use the System File Checker tool to troubleshoot missing or corrupted system files on Windows Vista or on Windows 7

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