Can anyone help - LR5.3 won't start after only 2 successful days!!

2 days ago installed LR5.3 trial on my new PC bought to run LR and CS6 - Win 7 Pro, Xeon E3-1230, 32gb memory, SSDs etc (the works).
Worked great for 2 days, cataloging a big trip, lots of adjustments made. Yesterday I found LR had unexplained errors and dropped/closed but I was able to restart it and my catalogs opened and allowed further actions, and all was well.
Now today the PC doesn't run LR5.3 from the desktop icons or from the .exe files which I locate via Explorer. I tried repair of LR5.3 from Adobe installer program - no improvement after the repair - and then did a full reinstall from the Adobe installer but again no recognition/operation of LR, either when I click on the desktop icon or go to the .exe files.
My other software (minimal, no conflicts there) works fine from the programs' exe files and my internet browsers are fine.
I now have brand new computer with no LR after two positive days.
Can anyone help out there?

Reply to Rikk and Geoff
Thank you. Went to .lrcat in WinExplorer and it opened and brought in all my previews and camera calibrations etc
Now I'll seek to remember whatever the preferences were.
2 Questions for you
1. Geoff the big catalog guy - if I decide to use one catalog I imagine it will be simple to import and merge other catalogs into the big catalog (probably 200k images to assemble into the catalog)
2. For both of you - given the weird location of the prefs, are there any other quirks I need to remember in my backup regime - I already have my lrcat and lrdata (previews) as well as images on another backup pc. anything else I should be offline backingup?

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