Can change the price in the PO line item

Hello experts,
I have this Purchase order document where I can change the price in the PO line item(ME22N) where as in the other PO that I have created, changing the price in ME22N is not possible(shaded). They are all the same document type and plant combination. For the PB00 condition type configuration, It is set to D- not possible to process manually.
Please help.

Thanks for your answer. Yes i am aware of that, basically the settings is what the price indicated in the info record and as long it is included in the validty periiod then when you create the PO, that price will be detected by the system. i am clear for that, my issue is why there are some materials that i can change the price in the PO directly while the others are the pricing tab is disabled(cannot change the price)
Settings in the SPRO-MM - PURHASING- CONDITIONS-DEFINE PRICE DETERMINATION PROCESS- DEFINE CONDITION TYPES PB00 is D(NOT POSSIBLE TO PROCESS MANUALLY) but stilll the system is showing some PO's that can be changed the price

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