Can I delete a media cache file that has caused my backup program to fail?

There are 2 Adobe Premere files that are located under App Date, Media Cache files that are causing my backup program to fail. These files were created in August of 2010 and have been backed up successfully many times. However as of Dec 2011 the backup program has failed to complete and the problem has been traced to these two files. I have no idea what the files do but deleting them would be good if it isn't going to affect my Photoshop Elements or premere Elements or my picture files and their location. It appears that the files are tiny clips from music that I may have opened when creating a movie with music to go with the slides. The actual clip of music does not seem to appear in any of the movies I created, which is a bit baffeling. I'd appreciate any help on this. Thank you.

Hi,
Can you share the name and path of the files?
Are you talking about Mediadatabase.db3 file present at: application data\adobe\Photoshop Elements\10.0Locale\en_US? If yes, you can delete this file. When you launch Photoshop Elements the next time, this file will automatically get created for you.
Thanks

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