Can I delete USR,share,private files?

Searching for causes of lost space, running app WhatSize, I found that several files were pretty large. All the "USR" files come to 400MB, the "private" (var etc) come to 75MB, followed by "dev" "bin", "mach kernel" and "sbin".
Is it at all safe to delete these? and will they be recreated by a restart?
thanks

Also:
Some of them vary in size. If you run WhatSize again, it may show a different figure, depending what your computer is doing at the moment.
DPSG-Scout is right about caches, but do not search in these folders.
Some caches that can grow that you can delete with no problem: the users caches. ~/Library/Caches separately from each user.

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