Can I just delete older versions of QuickTime.msi ?

My hard drive is filling up, so in trying to free space, I searched for larger files.
I have at least 12 versions of QuickTime.msi in <applecomputer\installer cache\itunes folders, with versions ranging from 7.0.2.16 through 7.5.0.20. Each file is over 24MB. I also have several other apple, quicktime, and itunes files over 24MB in my Temporary Internet Files\content.ie5 folders, with fairly recent 'last modified dates'.
iTunes works fine on my PC. Can I just delete all but the latest version of Quicktime.msi and all of the cache files without major risk of screwing things up?

Thank you very much.
As for adding a hard drive (I'd probably add a USB drive to my Dell laptop), I'm considering it, however a) I haven't figured out how to tell iTunes to use the new drive and b) if I get a new hard drive, I may not have a reason to by a new Mac like I've been considering

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